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Systematic Reviews, Scoping Reviews, and other Knowledge Syntheses

What Is supplemental searching?

What is supplemental searching?

Finding studies relevant to your question should not depend solely on database searching: Supplementary search methods are recommended in order to avoid different forms of bias in what studies are ultimately included in the review.

Examples of supplementary search methods:

Finding grey literature

Finding grey literature

Grey literature, according to the Cochrane Handbook, is usually understood to be literature not formally published in books or journals. This can include theses or dissertations, conference proceedings, clinical trials registries, white papers, government reports, and more. Some grey literature will be retrievable through database searching, but it depends on the databases you have chosen to search and what kind of content the databases index. For example, MEDLINE does not index much grey literature, whereas you can retrieve some conference proceedings indexed in Web of Science Core Collection databases available through McGill.

You may be interested in finding grey literature available on websites. One suggestion is to identify associations, organisations, institutions, etc. that are likely to make documents or reports of relevance to your question available on their websites, and to then selectively search or browse those sites.

Resources to help you identify grey literature:

Grey Matters: A Practical Search Tool for Evidence-Based Medicine, 2019, Canadian Agency for Drugs and Technologies in Health (CADTH)

Resources to help you identify grey literature for interventions in crime & justice, education, international development, and social welfare:

Searching for Studies: A Guide to Information Retrieval for Campbell Systematic Reviews, 2017

Resources to help you identify Canadian health policy:

A guide to governmental and grey literature sources for public policy research, University of Toronto

For more information on searching the grey literature, the University of Toronto Gerstein Science Information Centre has a comprehensive guide on searching the grey literature, including lists of potential resources to search.

Finding theses & dissertations

Theses and dissertations are potentially rich sources of grey literature given the depth of research involved in writing a thesis or dissertation. They are also usually considered grey literature in and of themselves.

Searching clinical trials registries

Searching clinical trials registries

Clinical trials may go unreported in the published literature. One useful method to identify unpublished clinical trials is to search clinical trials registries. The results may be available within the registries or you may need to contact the researchers associated with the trial for further information.

International Clinical Trials Registry Platform (WHO)

For more information on what and how to search for randomized controlled trials of new drugs, see:

Knelangen M, Hausner E, Metzendorf M-I, Sturtz S, Waffenschmidt S. Trial registry searches for randomized controlled trials of new drugs required registry-specific adaptation to achieve adequate sensitivity. J Clin Epidemiol. 2018;94:69-75.

Searching for citation relationships

Searching for citation relationships

Searching for citation relationships includes at least five approaches to finding references that you may not have picked up through your database searching. This can be especially important if your database search strategies were not exhaustive, if the literature on your topic is dispersed across multiple databases or subject areas, or if the vocabulary used by authors is highly heterogenous for a given idea.

Reference list searching

  • This method is probably the most widely known supplementary approach to finding literature on a given topic; it is usually limited to searching the reference lists of included studies, and therefore takes place after screening

Included studies in other relevant knowledge syntheses

  • This is another accepted method of searching for relevant literature

Similar articles feature

  • PubMed includes a similar articles feature that can be used to track further studies. Other databases may also have this functionality

Co-cited article searching

  • Searching the reference lists of articles citing included studies may be useful, if not even more useful than reference list searching or forward citation searching (

Forward citation searching

  • This method involves copying and pasting, for example, the titles or PMIDs of included studies into a citation database to see who has cited the included study of interest

Forward citation searching is available as a feature in the following resources:



Handsearching is a term that predates online tables of contents and generally involves reading the tables of contents of journals that are highly likely to publish literature on your topic. This may pick up studies that were missed by the database searches, for example because they used terms that you did not include in your search strategy or because the journal is not indexed in the databases you chose to search (that said, it is a good idea to search databases that index the journals relevant to your topic).

We recommend the Cochrane free online course on Hand Searching to help you find:

  • Conference proceedings
  • Major journals
  • Relevant, non-indexed journals


Belter, C. W. (2016). Citation analysis as a literature search method for systematic reviews. Journal of the Association for Information Science and Technology, 67(11), 2766-2777. Retrieved from doi:10.1002/asi.23605

Cooper, C., Booth, A., Britten, N., & Garside, R. (2017). A comparison of results of empirical studies of supplementary search techniques and recommendations in review methodology handbooks: a methodological review. Syst Rev, 6(1), 234. doi:10.1186/s13643-017-0625-1

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