When using this model to guide clinical decision making, begin your search at the highest possible layer in the 6S model.
Read this article for an overview of the 6S model and how it relates to your search for best evidence to inform clinical practice.
DiCenso, A., Bayley, L., & Haynes, B. (2009). Accessing pre-appraised evidence: fine tuning the 5S model into a 6S model. Evidence-Based Nursing, 12(4), 99-101.